Version2.1 2021-01-14T13:18:36Z 10.1021/jm300687e Gaussian16 RevisionB.01 CFLINN 22-Dec-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE Cc1cc(c(c(c1)Cl)N(c2nc(cs2)CSc3nnnn3c4ccc(cc4)O)C(=O)C)C C25045614 RHF 6-31G(d) (6D,7F) Cc1cc(c(c(c1)Cl)N(c2nc(cs2)CSc3nnnn3c4ccc(cc4)O)C(=O)C)C C01[X(C21H19Cl1N6O2S2)] 147 C1 530 Oc1ccc(cc1)n1nnnc1SCc1csc(n1)N(c1c(C)cc(cc1Cl)C)C(=O)C Oc1ccc(cc1)n1nnnc1SCc1csc(n1)N(c1c(C)cc(cc1Cl)C)C(=O)C CC(=O)N(c1scc(CSc2nnnn2c3ccc(O)cc3)n1)c4c(C)cc(C)cc4Cl InChIKey=UEPUVRUWDAIXDS-UHFFFAOYSA-N InChI=1S/C21H19ClN6O2S2/c1-12-8-13(2)19(18(22)9-12)27(14(3)29)20-23-15(10-31-20)11-32-21-24-25-26-28(21)16-4-6-17(30)7-5-16/h4-10,30H,11H2,1-3H3 InChI=1/C21H19ClN6O2S2/c1-12-8-13(2)19(18(22)9-12)27(14(3)29)20-23-15(10-31-20)11-32-21-24-25-26-28(21)16-4-6-17(30)7-5-16/h4-10,30H,11H2,1-3H3 Cc1cc(c(c(c1)Cl)N(c2nc(cs2)CSc3nnnn3c4ccc(cc4)O)C(=O)C)C C01[X(C21H19Cl1N6O2S2)] 147 C01 530 Oc1ccc(cc1)n1nnnc1SCc1csc(n1)N(c1c(C)cc(cc1Cl)C)C(=O)C O[C]1[CH][CH][C]([CH][CH]1)[N@]1[N][N][N][C]1SC[C]1=CS[C](=[N]1)N([C]1[C]([CH][C]([CH][C]1Cl)C)C)C(=O)C C[C]1[CH][C](C)[C]([C](Cl)[CH]1)N(C(C)=O)c2scc(CS[C]3[N][N][N]N3[C]4[CH][CH][C](O)[CH][CH]4)n2 InChIKey=UEPUVRUWDAIXDS-UHFFFAOYSA-N InChI=1S/C21H19ClN6O2S2/c1-12-8-13(2)19(18(22)9-12)27(14(3)29)20-23-15(10-31-20)11-32-21-24-25-26-28(21)16-4-6-17(30)7-5-16/h4-10,30H,11H2,1-3H3 InChI=1/C21H19ClN6O2S2/c1-12-8-13(2)19(18(22)9-12)27(14(3)29)20-23-15(10-31-20)11-32-21-24-25-26-28(21)16-4-6-17(30)7-5-16/h4-10,30H,11H2,1-3H3 3557.1821383936 -2537.1524785 1-A 24074.7248 126 404 530 |A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A|A| -104.83892 -91.98497 -91.96690 -20.60595 -20.54524 -15.66650 -15.64060 -15.62758 -15.62081 -15.57878 -15.56641 -11.36678 -11.35398 -11.33975 -11.32229 -11.31821 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64.506965 25 6 7 16 17 6 2
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|1.185972|1.306963|1.390937|1.546975|1.609991|1.484000|1.345105|12.123093|2.482087|1.920352|2.840047|2.108272|1.941128|12.711639|2.267285|20.612676|2.932367|3.399816|3.462419|4.091003|4.685743|4.635598|5.224942|7.947160|14.141953|8.149739|5.287155|73.516695| |2.889605|3.722317|4.223626|5.884167|7.701195|5.543210|4.083805|40.282176|18.435621|7.842020|8.894043|4.500552|3.990849|34.226376|3.603376|24.524476|2.693606|3.342956|2.900683|2.860127|3.256783|2.349210|2.074921|1.978315|2.098637|2.385814|2.555309|3.468815|36.858105| |2.466015|3.051478|3.438205|4.532306|5.380901|4.191316|3.279110|32.313994|11.426262|6.895897|9.068688|4.677041|3.987291|31.589123|3.871325|28.309053|3.006179|3.620838|3.133513|3.136399|3.651450|2.678713|2.335317|2.232999|2.402868|2.784716|2.983052|3.944246|16.062204|73.516695| |3.044471|3.877054|4.288465|5.521888|6.676846|5.413704|4.224674|38.665226|10.473743|5.071615|6.048131|3.377117|3.088714|26.047413|2.862316|19.582328|2.271972|2.870754|2.547860|2.517261|2.809454|2.039012|1.821992|1.757127|1.872679|2.112428|2.223850|3.144310|12.588302|14.302667|36.858105| |3.788361|5.007424|7.587923|12.591049|7.505921|5.008666|4.428962|29.098080|8.924143|5.176955|5.350435|3.366522|3.553715|35.686237|2.691114|18.174722|2.076573|2.627977|2.328703|2.296481|2.561127|1.865516|1.729424|1.675277|1.739735|1.879658|1.953358|2.943472|5.726649|8.544684|5.100368|36.858105| |17.537475|8.866496|6.260102|4.435396|3.974924|4.472939|6.300681|27.336794|4.183226|2.670867|3.143890|2.095454|2.178282|18.900201|1.820303|11.769690|1.466253|1.952415|1.777046|1.719396|1.832385|1.306063|1.220937|1.176941|1.206270|1.288797|1.345583|2.054565|2.775064|4.223669|3.027836|3.492459|0.500000| |17.580551|8.841156|5.651289|4.187640|3.953551|4.716349|7.106884|29.438913|4.168075|2.776847|3.270740|2.224477|2.356150|20.455547|1.923747|12.142080|1.518371|2.042865|1.850723|1.773975|1.881668|1.326695|1.240172|1.185684|1.204509|1.283934|1.352319|2.038063|2.655415|4.073421|2.760584|3.250120|0.302016|0.500000| |17.580953|8.844664|7.108886|4.703408|3.957609|4.211982|5.649326|25.322775|4.169833|2.750712|3.191766|2.173222|2.329066|20.690978|1.866614|12.019455|1.488861|1.980781|1.797395|1.737497|1.855151|1.321529|1.242954|1.196780|1.218781|1.293209|1.350323|2.073700|2.683386|4.141555|2.776749|3.779873|0.301966|0.301516|0.500000| |7.026311|8.945841|17.710856|8.962980|5.655114|4.991309|5.672605|27.533765|5.670175|3.525937|3.893105|2.571048|2.757057|26.127719|2.142668|14.049499|1.687593|2.199677|1.978272|1.930027|2.097061|1.509657|1.414049|1.367714|1.404942|1.499393|1.558722|2.391351|3.613396|5.441382|3.684223|7.102145|0.168147|0.143839|0.214558|0.500000| |6.982533|8.886773|5.658514|4.932661|5.634294|8.971824|17.744196|54.769885|5.669000|3.658897|4.274122|2.788208|2.856797|24.882779|2.371177|14.528835|1.797314|2.424519|2.165123|2.058229|2.193313|1.528456|1.403741|1.328687|1.354552|1.466390|1.567141|2.267460|3.471481|5.110585|3.624430|3.544352|0.168631|0.211778|0.142791|0.124290|0.500000| |2.230917|2.608075|2.748497|3.159614|3.502283|3.230559|2.793911|26.020242|5.371298|5.482147|7.784051|8.766808|17.806644|54.957243|6.563044|33.289226|3.683907|4.879394|3.943672|3.637560|4.063180|2.676983|2.452748|2.185528|2.107014|2.245403|2.532879|3.348088|3.267625|5.836431|2.636776|3.098884|0.056148|0.061302|0.060707|0.069912|0.071796|0.500000| |1.856741|2.136904|2.202100|2.512438|2.867706|2.731629|2.344090|24.097997|4.588531|4.410475|7.700621|8.910966|7.117914|31.139809|17.665914|56.367292|6.716541|9.522689|6.453531|5.525417|6.264933|3.678168|3.168469|2.654952|2.515030|2.749923|3.326243|3.842223|3.049761|5.716984|2.496693|2.459972|0.048014|0.051287|0.049727|0.056040|0.061871|0.200736|0.500000| |1.930701|2.248093|2.292095|2.643502|3.141238|3.036270|2.531654|28.543830|5.207291|4.911237|9.644773|8.940441|5.812543|29.652851|17.648545|56.446933|6.625439|9.199284|6.320953|5.467142|6.235811|3.681085|3.021012|2.570791|2.524116|2.874795|3.543766|3.861508|3.553967|6.690188|2.890409|2.534695|0.050395|0.053244|0.050882|0.057465|0.067078|0.141656|0.301334|0.500000| |1.237941|1.367625|1.433403|1.589983|1.689587|1.585149|1.430189|13.274084|2.607643|2.137739|3.282750|2.652742|2.435818|14.671906|3.135964|29.338208|5.189741|5.976151|6.623872|8.908038|9.850512|8.945095|17.741465|8.915152|5.646822|4.951412|5.649722|7.480324|1.941447|3.828734|1.709483|1.654362|0.033004|0.033737|0.033752|0.038062|0.037984|0.068397|0.088679|0.081472|0.500000| |1.157073|1.270975|1.343413|1.485204|1.550823|1.442601|1.312113|11.858927|2.374702|1.889580|2.819229|2.187403|2.040683|12.905258|2.428812|22.098247|3.382630|3.958871|4.180179|5.118691|5.692568|5.655957|8.926927|17.700004|8.893971|5.632010|4.952254|12.726797|1.805289|3.581816|1.616423|1.572188|0.031066|0.031314|0.031695|0.036040|0.034724|0.056505|0.066720|0.063626|0.214999|0.500000| |1.336102|1.493316|1.588024|1.795108|1.909787|1.752119|1.558291|14.547502|3.027726|2.330578|3.541372|2.544700|2.246566|14.691186|2.761097|26.189735|3.604243|4.025115|3.971115|4.669892|5.666040|5.642597|4.952196|5.649638|8.947587|17.749967|8.899142|13.310745|2.456242|5.137031|2.201721|1.906568|0.036229|0.035793|0.036126|0.042091|0.040907|0.058863|0.070154|0.074934|0.107543|0.124202|0.500000| |1.462361|1.653694|1.738464|1.983832|2.182415|2.022825|1.764366|17.399879|3.548843|2.841905|4.607686|3.367335|2.801631|17.415952|3.961631|41.574035|6.117988|6.221003|5.895369|7.055561|9.748407|8.914968|5.648275|4.955275|5.654210|8.943475|17.737702|7.584371|2.825732|5.928198|2.448244|2.051688|0.039337|0.039478|0.039185|0.045299|0.046471|0.072496|0.097059|0.110418|0.124331|0.107540|0.214232|0.500000| |1.138400|1.248790|1.327577|1.468186|1.520152|1.405320|1.281061|11.444032|2.323736|1.801433|2.646615|1.982609|1.847403|12.094652|2.128228|19.008668|2.730675|3.214884|3.301369|3.880722|4.346609|4.177742|4.986362|7.778835|10.001277|6.056872|4.435031|35.756014|1.808486|3.616727|1.644427|1.570971|0.030790|0.030613|0.031192|0.035787|0.033800|0.050242|0.057052|0.056440|0.116578|0.229731|0.152238|0.101041|0.500000| |3.391859|4.368825|5.071831|6.530166|6.915745|5.426162|4.486377|35.006173|9.207935|4.544499|5.233261|3.049170|2.895301|25.188762|2.576304|17.624406|2.063553|2.619477|2.341019|2.315274|2.568984|1.872957|1.697273|1.647344|1.748684|1.944100|2.024093|2.962388|8.791562|11.039868|17.595707|6.059469|0.094759|0.082971|0.086225|0.121627|0.104194|0.069615|0.063606|0.071298|0.044469|0.042438|0.056156|0.060945|0.043307|0.500000| |2.630028|3.205188|3.508483|4.297423|4.871165|4.160132|3.426241|31.527039|7.725649|4.226985|5.358171|3.074815|2.779230|22.450426|2.699287|19.137004|2.245892|2.815568|2.524320|2.520797|2.819290|2.074002|1.849605|1.799858|1.943973|2.211479|2.301559|3.284559|9.051705|13.727572|17.642699|4.240540|0.073512|0.066877|0.067530|0.087058|0.084436|0.066844|0.065464|0.076051|0.047820|0.045863|0.065028|0.070766|0.047432|0.300148|0.500000| |3.181457|4.054961|4.195028|5.096164|6.590140|6.139109|4.698383|47.168237|9.471503|4.805182|5.855615|3.294192|3.000505|24.943103|2.823404|18.757818|2.220364|2.852004|2.532791|2.477879|2.733493|1.957468|1.745436|1.671524|1.768749|1.991990|2.117137|2.959449|8.867071|10.965364|17.582222|4.340065|0.088466|0.081321|0.078621|0.098165|0.114310|0.071485|0.068693|0.080972|0.045741|0.042769|0.057342|0.065004|0.043114|0.302225|0.299093|0.500000| |3.280986|4.219665|5.747364|8.798160|6.844124|4.619742|3.946327|28.459238|9.550741|6.114497|6.158725|3.908650|4.203722|43.841461|3.037130|20.623716|2.294658|2.872702|2.521317|2.489323|2.806518|2.044345|1.892008|1.824562|1.888027|2.040661|2.131824|3.170721|5.914737|9.372106|4.716849|17.609633|0.083441|0.080920|0.091058|0.148430|0.089992|0.100120|0.076716|0.077653|0.050238|0.047413|0.057081|0.061981|0.046965|0.142918|0.111652|0.111666|0.500000| |3.416805|4.360559|6.079516|8.824134|6.437856|4.505826|3.967668|27.478214|8.355286|4.662872|5.061103|3.128596|3.176735|29.676529|2.566698|17.808828|2.042951|2.567395|2.289741|2.276119|2.545354|1.874213|1.733183|1.693051|1.779551|1.934493|1.991188|3.030478|6.264103|9.419747|5.961157|17.542593|0.090955|0.081793|0.093423|0.161318|0.090388|0.077175|0.064631|0.067850|0.045697|0.044027|0.055150|0.058333|0.044714|0.210715|0.140261|0.131786|0.303006|0.500000| |3.837970|4.781832|7.323766|8.885222|5.582388|4.196382|3.991759|25.021505|6.566312|4.122219|4.462831|2.929108|3.152239|30.575825|2.397663|16.284241|1.895782|2.413170|2.157922|2.131075|2.359047|1.724053|1.617499|1.575334|1.628769|1.738702|1.792706|2.776007|4.326539|6.772242|4.041751|17.597080|0.098012|0.090362|0.111453|0.227146|0.090798|0.078786|0.061997|0.062658|0.043208|0.041395|0.048892|0.051791|0.041417|0.132449|0.097348|0.098900|0.301853|0.302548|0.500000|
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