Version2.4 2021-05-28T10:07:22Z 10.1021/jm300687e Gaussian16 RevisionB.01 PWARBURT 04-Nov-2020 #N HF/6-31G(d) OPT=(MaxStep=1) FREQ IOp(6/10=2,6/11=2,6/12=2) DUDE Cc1c(sc(n1)N2[C@H](C(=C(C2=O)[O-])C(=O)c3ccc(cc3)F)c4cccs4)C(=O)OCC=C C08779272 RHF 6-31G(d) (6D,7F) Cc1c(sc(n1)N2[C@H](C(=C(C2=O)[O-])C(=O)c3ccc(cc3)F)c4cccs4)C(=O)OCC=C C01[X(C23H16F1N2O5S2)] 141 C1 535 C=CCOC(=O)c1sc(nc1C)N1[C@@H](c2cccs2)C(=C(C1=O)[O-])C(=O)c1ccc(cc1)F C=CCOC(=O)c1sc(nc1C)N1[C@@H](c2cccs2)C(=C(C1=O)[O-])C(=O)c1ccc(cc1)F Cc1nc(sc1C(=O)OCC=C)N2[C@@H](c3sccc3)C(=C([O-])C2=O)C(=O)c4ccc(F)cc4 InChIKey=FWOQNYNKOMGVCI-KRWDZBQOSA-M InChI=1S/C23H17FN2O5S2/c1-3-10-31-22(30)20-12(2)25-23(33-20)26-17(15-5-4-11-32-15)16(19(28)21(26)29)18(27)13-6-8-14(24)9-7-13/h3-9,11,17,28H,1,10H2,2H3/p-1/t17-/m0/s1 InChI=1/C23H17FN2O5S2/c1-3-10-31-22(30)20-12(2)25-23(33-20)26-17(15-5-4-11-32-15)16(19(28)21(26)29)18(27)13-6-8-14(24)9-7-13/h3-9,11,17,28H,1,10H2,2H3/p-1/t17-/m0/s1/fC23H16FN2O5S2/h28h/q-1 Cc1c(sc(n1)N2[C@H](C(=C(C2=O)[O-])C(=O)c3ccc(cc3)F)c4cccs4)C(=O)OCC=C C01[X(C23H16F1N2O5S2)] 141 C01 535 C=CCOC(=O)c1sc(nc1C)N1[C@@H](c2cccs2)C(=C(C1=O)[O-])C(=O)c1ccc(cc1)F C=CCOC(=O)[C]1[C]([N][C](S1)N1C(=O)[C]([C]([C](=O)[C]2[CH][CH][C]([CH][CH]2)F)[C@@H]1C1=[CH][CH]=CS1)=O)C C[C]1[N][C](S[C]1C(=O)OCC=C)N2[C@H]([C](C(=O)[C]3[CH][CH][C](F)[CH][CH]3)C(=O)C2=O)c4sccc4 InChIKey=YXMCJHKGJVNFQO-KRWDZBQOSA-N InChI=1S/C23H16FN2O5S2/c1-3-10-31-22(30)20-12(2)25-23(33-20)26-17(15-5-4-11-32-15)16(19(28)21(26)29)18(27)13-6-8-14(24)9-7-13/h3-9,11,17H,1,10H2,2H3/t17-/m0/s1 InChI=1/C23H16FN2O5S2/c1-3-10-31-22(30)20-12(2)25-23(33-20)26-17(15-5-4-11-32-15)16(19(28)21(26)29)18(27)13-6-8-14(24)9-7-13/h3-9,11,17H,1,10H2,2H3/t17-/m0/s1 3668.7685133922 -2257.9714281 1-A 17425.6083 125 410 535 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363.8995 378.9013 391.1115 398.1932 431.6927 446.6803 458.9461 469.4572 491.3376 526.7729 552.5061 556.5862 568.6409 587.5530 613.0173 641.1698 658.6548 663.2833 681.9418 692.8144 707.7995 720.3088 725.0240 741.1114 776.2079 789.8520 799.2897 816.0168 832.4606 859.6190 862.8889 873.1325 891.7372 904.1310 906.9454 921.2472 930.2330 932.5240 959.7922 968.6604 1018.2311 1035.9803 1061.8180 1076.6662 1079.8318 1087.2208 1101.8698 1112.4631 1122.9111 1125.6738 1129.1766 1146.8294 1158.5622 1175.8466 1177.8020 1203.5144 1221.1396 1241.5073 1255.6306 1274.9574 1284.2875 1288.0593 1298.1324 1315.6660 1359.4194 1365.8193 1369.5885 1385.6255 1393.3260 1423.8993 1435.5125 1438.6881 1465.7170 1476.1867 1511.2940 1533.3757 1535.8579 1546.9472 1556.0464 1564.6108 1606.2470 1614.8128 1635.3251 1641.5423 1649.9563 1657.9761 1689.7275 1754.2575 1760.5832 1786.1219 1815.5270 1823.9547 1886.1539 1950.0012 1954.4542 2042.1475 3204.7446 3220.2273 3248.8307 3271.3974 3300.6534 3328.3870 3354.5944 3365.9037 3374.0051 3380.8016 3382.2241 3392.1785 3399.7164 3403.9134 3409.0701 3431.2468 5.9672 7.5241 8.2984 7.2831 5.6822 4.5249 5.2865 5.9126 4.5395 6.2725 5.4599 5.0114 9.8590 1.1002 5.6659 4.7353 7.6545 5.2980 5.4008 7.5921 6.3045 6.2899 5.1770 5.1634 6.6517 4.8588 8.3336 7.5017 9.3508 10.1624 5.8671 6.2802 7.2639 7.2772 5.9447 4.2415 3.1167 4.8374 6.0542 4.5293 7.5877 5.9718 4.0169 5.2870 3.9658 4.9423 5.4160 10.2937 6.9767 1.7513 5.9061 6.0314 7.7737 6.5533 5.6279 1.2007 6.7322 6.3672 5.9140 7.4556 6.8687 7.5204 6.4774 7.2662 7.0078 1.2540 4.2821 1.8418 1.5033 1.4589 1.3541 4.5731 1.5045 1.4464 1.5883 1.3528 3.4778 2.4626 2.2197 2.2292 1.4724 2.6086 1.5819 1.6857 1.2889 5.1571 4.6695 5.8821 1.1940 1.9396 3.9344 8.3846 5.1588 1.6906 5.3295 3.5716 2.6170 1.1017 2.6752 1.3051 1.6360 1.4716 4.7646 2.2518 1.6823 1.4444 3.4360 1.9564 2.7160 1.2605 1.2808 1.0465 6.2042 4.5011 1.0992 2.7626 6.9294 5.3534 7.1761 5.8022 12.3448 4.3827 12.7426 12.4015 13.0925 1.0839 1.0418 1.0601 1.1012 1.1068 1.0613 1.0957 1.0988 1.0893 1.0896 1.0908 1.0959 1.0956 1.0952 1.1159 1.0992 0.0003 0.0016 0.0030 0.0040 0.0041 0.0046 0.0073 0.0089 0.0121 0.0197 0.0199 0.0206 0.0473 0.0061 0.0394 0.0360 0.1140 0.0882 0.1118 0.1709 0.1741 0.2071 0.1828 0.1924 0.2907 0.2382 0.5033 0.4685 0.6469 0.7929 0.4963 0.5660 0.6786 0.7990 0.6988 0.5264 0.4047 0.6881 0.9898 0.8146 1.3849 1.1377 0.8170 1.1706 0.9606 1.2633 1.4039 2.8204 1.9730 0.5169 1.8055 1.8680 2.5156 2.3263 2.0687 0.4520 2.6412 2.5997 2.5748 3.2707 3.0852 3.5234 3.1197 3.5214 3.5041 0.6393 2.1939 0.9997 0.8311 0.8912 0.8563 3.0378 1.0276 0.9937 1.1062 0.9677 2.5359 1.8295 1.6571 1.6746 1.1410 2.0630 1.2886 1.3778 1.1000 4.5309 4.2405 5.4640 1.1435 1.8849 3.8459 8.3248 5.2613 1.8408 5.8577 3.9473 2.9603 1.2601 3.1957 1.5846 1.9951 1.8627 6.1173 3.0302 2.3305 2.0075 4.8446 2.7910 3.9173 1.9161 1.9677 1.6489 9.8500 7.2196 1.7803 4.6472 12.5641 9.7768 13.4883 11.2681 24.1970 9.1864 28.5482 27.9111 32.1697 6.5588 6.3652 6.5924 6.9435 7.1041 6.9270 7.2645 7.3344 7.3063 7.3373 7.3518 7.4301 7.4611 7.4763 7.6407 7.6252 0.1858 0.1509 0.1416 0.2249 0.5650 0.4962 0.1410 0.6264 0.4115 1.1814 4.0640 1.4924 0.7133 0.1354 0.1861 1.5524 1.1565 0.3794 5.2181 1.3745 2.6074 5.3366 0.3122 4.0347 0.6648 1.8152 5.7079 1.6711 1.6704 0.2272 19.3268 12.2430 1.8602 0.9259 4.8436 7.7085 0.3728 9.2071 7.5117 4.7623 19.8650 14.0587 15.3329 4.6473 1.3637 26.3261 4.6383 2.3102 1.1760 8.5459 8.8414 9.8704 16.9559 8.2567 13.4425 71.2160 6.9496 33.7728 2.8672 48.0440 46.1061 7.5456 11.5872 57.6555 61.7346 1.0828 4.2480 37.0398 3.5163 4.2962 2.2143 12.7450 40.3084 0.4360 23.8759 3.4323 16.3193 59.4336 8.9477 2.8818 58.0050 7.5738 3.7661 4.9867 1.0548 390.0015 155.0270 89.6226 18.2952 1.0771 2.1955 75.3266 23.3821 27.8024 109.5431 133.7389 344.1843 2.4569 901.9260 10.9904 330.1660 46.5924 219.2893 264.7240 25.7089 15.8651 562.5325 132.0371 452.2793 31.7362 182.4866 4.5888 35.0224 562.0305 12.6144 39.3518 186.2390 1.5965 6.9621 59.5959 410.4880 3.1746 921.0365 288.1147 471.5394 37.7760 21.7983 27.6851 16.8133 18.9755 21.2083 6.0171 4.4001 12.6727 16.2763 10.6359 13.6212 10.8987 7.2219 22.6653 10.2336 1.4390 0.2209 0.9159 2.5724 2.7487 3.4429 1.2943 6.6211 7.2955 2.2337 0.9043 0.8553 0.6040 1.0247 4.5700 1.5872 1.8135 2.5237 0.5947 1.0190 2.3337 1.3538 1.0966 1.3964 1.8442 1.0306 4.1429 3.8664 1.5748 2.0251 3.7606 1.3640 3.4039 0.8972 0.1786 3.7242 0.5096 3.1971 2.0337 0.8717 0.5611 1.0915 2.6380 15.1015 0.2054 1.9536 1.6346 11.6828 4.7069 8.5855 5.1915 1.5545 3.1221 0.3183 1.5694 2.0902 4.6150 5.7959 2.5376 1.1347 8.7811 3.5766 10.3767 7.6409 10.2239 2.8029 4.1978 0.9467 1.4695 6.6524 2.6104 4.6383 2.2417 2.0829 2.2923 0.2313 0.9227 0.8764 2.7836 1.4501 3.3869 49.1098 2.4424 2.2880 12.0968 9.8336 4.5961 1.8722 4.7687 3.1619 1.3476 3.0648 21.7544 10.2035 26.0525 2.8000 18.6572 20.1749 123.0175 2.3534 100.5575 6.4501 114.4685 8.1255 7.1425 10.6789 41.4844 48.8804 20.8281 7.5640 90.7184 14.8416 105.7161 354.8613 4.4279 0.9036 54.3777 4.3660 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MUNgauss RevisionA2.1 retrievium 28-May-2021 DUDE Cc1c(sc(n1)N2[C@H](C(=C(C2=O)[O-])C(=O)c3ccc(cc3)F)c4cccs4)C(=O)OCC=C C08779272 RHF 6-31G(d) (6D,10F) C1 483.048469 |X|Y|Z| 71.348226 102.947712 41.672858
67.393455 22 6 7 16 18 2 2
|36.858105| |12.713629|36.858105| |7.417866|14.015935|36.858105| |4.735503|7.488652|10.896767|388.023441| |5.340101|8.672789|7.823566|77.646700|36.858105| |7.831816|13.978091|8.265375|52.869953|14.815959|53.358707| |3.990701|5.428099|5.042956|49.948768|13.940554|11.044671|53.358707| |3.158998|4.082872|4.127955|43.090604|7.627660|7.076874|17.593578|36.858105| |3.056537|3.990092|4.299721|49.162520|6.995414|6.478807|12.425550|17.544197|0.500000| |2.679936|3.260991|3.199431|29.859192|5.204761|5.544156|11.075326|12.556980|0.241704|36.858105| |2.810277|3.345064|3.128860|27.364070|5.170146|5.882686|10.980058|7.893449|0.166519|13.524604|36.858105| |3.616091|4.480753|3.969474|34.226143|7.798015|8.791459|18.491035|7.961306|0.170016|8.067013|12.374544|36.858105| |3.909297|4.609921|3.866500|30.332528|6.657366|9.004572|11.254758|5.397459|0.126928|5.434490|7.785594|16.096320|73.516695| 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|3.036124|3.827819|3.899707|38.086510|6.141981|6.315720|10.514265|12.545118|0.252589|7.437511|5.416195|5.458892|7.438123|7.300619|5.892341|7.950541|5.649698|4.785780|3.964165|3.745547|4.074296|5.010194|6.922837|36.858105| |2.827123|3.517541|3.783860|36.632823|4.974682|5.363895|7.313772|7.415154|0.201022|5.153338|3.973391|4.027228|5.873454|5.714992|4.656439|6.578591|5.111024|4.679111|4.211033|4.087509|4.321394|4.858623|7.704843|14.137054|36.858105| |2.602175|3.092282|3.244572|28.169451|3.929725|4.597054|5.593367|5.012644|0.131004|3.997053|3.295129|3.322252|5.047627|4.954509|3.784247|5.712045|4.065672|4.085164|3.800808|3.546051|3.505957|3.743742|6.988021|8.180936|13.264214|36.858105| |2.606492|3.028093|3.028500|25.187551|3.825082|4.630837|5.604235|4.795124|0.116732|4.051271|3.460942|3.465436|5.292733|5.260070|3.791749|5.895146|3.791345|3.830675|3.415246|3.082410|3.039416|3.336621|6.068957|7.674669|8.252094|14.175823|36.858105| |2.868114|3.396975|3.258523|27.791839|4.760017|5.609222|7.773808|6.682119|0.142258|5.723752|4.890332|4.834519|7.001865|7.088507|4.890256|7.414812|4.359159|4.086744|3.387720|3.051753|3.133961|3.679195|5.831731|10.957346|7.474899|7.459219|11.038816|388.023441| |5.963523|7.493494|13.050995|48.235851|4.918355|6.979656|4.995470|3.234186|0.095216|2.616744|2.539675|3.052076|5.334209|3.958598|2.255812|3.535116|2.248100|2.021323|1.937904|2.037452|2.260417|2.397450|4.277578|3.148668|3.202303|2.849877|2.626293|19.194874|36.858105| |6.153338|6.302427|8.027208|34.347861|3.982603|5.956001|4.222776|2.737431|0.079005|2.288614|2.257976|2.687168|4.806471|3.586597|1.997467|3.180241|1.978590|1.801652|1.732334|1.808334|1.979741|2.086371|3.830051|2.689711|2.720270|2.498353|2.347896|17.057357|15.938190|73.516695| |4.244860|5.259606|8.251881|46.995972|4.344027|5.660257|4.663708|3.195868|0.097673|2.579757|2.436210|2.828550|4.821423|3.792672|2.268875|3.535295|2.325282|2.096090|2.043980|2.190622|2.446733|2.538588|4.644459|3.129695|3.310133|2.910614|2.596928|18.535445|14.296687|15.305078|73.516695| |3.469535|3.914474|5.245121|31.616734|3.283764|4.370035|3.717596|2.602899|0.078762|2.177906|2.065541|2.337528|4.024419|3.277358|1.963771|3.108151|2.029675|1.863811|1.845718|1.983885|2.181288|2.211809|4.294485|2.583277|2.760781|2.512493|2.253945|15.773867|8.110233|12.885046|23.875143|36.858105| |2.803846|3.191117|4.105637|28.300994|2.942732|3.779936|3.467278|2.524742|0.077878|2.130010|1.983082|2.184394|3.703485|3.151914|1.960813|3.100401|2.076157|1.920673|1.938686|2.122843|2.333855|2.302591|4.671646|2.519052|2.760464|2.506594|2.203922|15.184010|5.289978|8.276112|14.396978|12.717740|36.858105| |2.429480|2.702012|3.326113|23.265710|2.531564|3.265890|3.056811|2.237220|0.068907|1.935458|1.812132|1.969333|3.359707|2.914452|1.805310|2.882556|1.916296|1.780628|1.811374|1.996555|2.191219|2.136509|4.451761|2.203960|2.386156|2.178798|1.937249|13.434245|4.080861|6.698133|9.776563|7.657291|14.461838|36.858105| |17.559868|9.014806|5.859125|29.767804|4.908181|9.628160|5.238721|3.011714|0.080640|2.633334|2.837313|3.681235|7.426511|4.587499|2.200246|3.562583|2.037877|1.826184|1.687870|1.707507|1.868041|2.062465|3.524949|2.813349|2.578837|2.362884|2.385752|19.018217|4.830519|8.839880|6.501930|3.065105|2.535478|2.248449|0.500000| |17.556712|9.004846|5.862240|29.771891|4.911084|9.640132|5.224323|3.077178|0.080871|2.633026|2.767409|3.517153|6.727902|4.424322|2.213127|3.574252|2.064449|1.878665|1.738138|1.740262|1.875572|2.058436|3.596546|3.054128|2.832973|2.675957|2.743022|21.414768|4.854212|8.888820|6.533417|3.083487|2.554021|2.219640|0.303131|0.500000| |17.685868|8.856009|6.946795|30.619687|4.383395|7.738595|4.600399|2.797908|0.076797|2.388445|2.462910|3.054773|5.759043|3.950221|2.039758|3.284729|1.946013|1.766840|1.661087|1.694349|1.842331|1.991557|3.539664|2.721858|2.608550|2.425838|2.394457|18.167888|6.725149|14.348562|8.133296|3.857188|3.002507|2.593386|0.298980|0.299092|0.500000| |1.836337|2.104365|2.140724|18.522191|2.740199|3.224943|4.433600|4.240064|0.111657|4.917379|3.800663|3.096048|4.647291|6.176034|7.135475|12.610652|8.956761|17.743409|8.925624|5.682440|4.955214|5.675223|9.591805|4.518734|4.283122|3.962693|3.932739|30.202830|1.903985|3.045329|3.465452|1.740207|1.775546|1.646016|0.049347|0.051138|0.047471|0.500000| |1.630515|1.853982|1.940590|16.588425|2.293190|2.731022|3.483151|3.188184|0.090846|3.300041|2.686939|2.366353|3.669600|4.393543|4.087606|6.890785|5.605045|8.849869|17.729814|8.957818|5.646964|4.955997|16.690733|3.438824|3.691294|3.535141|3.228196|22.030397|1.786124|2.866009|3.340525|1.717079|1.804822|1.693352|0.043495|0.045075|0.043019|0.212685|0.500000| |1.913092|2.251651|2.481276|22.653890|2.843281|3.250577|4.193759|3.831511|0.128433|3.664390|2.958508|2.737391|4.228988|4.663242|4.048387|6.119055|5.603975|4.954215|5.643977|8.965949|17.730096|8.832445|16.682388|3.563893|3.818066|3.136166|2.712868|19.706554|2.297122|3.572537|4.498203|2.277744|2.483349|2.362438|0.051181|0.050905|0.050899|0.107589|0.124636|0.500000| |2.280611|2.763426|2.963564|28.737376|3.893937|4.217415|6.318871|6.329910|0.228560|6.460561|4.712672|4.117993|5.988336|6.984862|6.907769|9.106377|8.931551|5.663442|4.955549|5.691147|8.939332|17.724383|9.602185|4.852881|4.525544|3.446018|3.108548|25.033338|2.578523|3.956134|4.844450|2.343599|2.420391|2.247933|0.061748|0.060392|0.058990|0.124652|0.107590|0.213459|0.500000| |2.745637|3.439148|3.878840|39.322683|4.734850|5.062128|6.681413|6.643152|0.212072|4.692376|3.639034|3.702850|5.482014|5.296428|4.342521|6.135763|5.084200|4.568236|4.348517|4.533932|4.984846|5.349584|8.599047|8.937972|17.740969|8.588349|5.739493|37.760759|3.362005|4.994507|6.449330|3.015301|3.102263|2.666441|0.069655|0.074822|0.071511|0.110877|0.104064|0.125222|0.139167|0.500000| |2.399372|2.796928|2.983881|25.101200|3.351155|4.018456|4.630360|4.010047|0.109396|3.313938|2.793861|2.819245|4.384734|4.296973|3.219488|4.975730|3.548096|3.672904|3.614745|3.433865|3.310525|3.369616|7.034239|5.707459|8.577985|17.732937|8.907013|37.691444|2.720206|4.282298|5.031891|2.503066|2.540951|2.210765|0.060420|0.068358|0.063286|0.098396|0.096081|0.083814|0.085871|0.201455|0.500000| |2.411798|2.714668|2.684636|21.395934|3.241419|4.077871|4.665795|3.817391|0.094556|3.391057|3.010225|3.007763|4.727484|4.720957|3.242097|5.235115|3.221647|3.339675|3.039415|2.729369|2.647355|2.850455|5.498086|5.400848|5.691131|8.773479|17.778433|55.339653|2.378385|3.854771|4.158605|2.069623|2.020851|1.790122|0.061549|0.071390|0.062031|0.097439|0.082130|0.066336|0.073976|0.122604|0.203535|0.500000| |3.414593|3.718560|4.773053|28.110150|3.051086|4.139240|3.479892|2.404317|0.072312|2.049698|1.972420|2.236027|3.908222|3.160205|1.849195|2.949858|1.893864|1.735292|1.713141|1.838181|2.024691|2.061430|3.982422|2.342652|2.451334|2.234022|2.037665|14.479749|7.190675|12.860428|16.486166|17.620640|8.875427|7.212206|0.085774|0.082970|0.107411|0.045155|0.044330|0.058879|0.061105|0.073538|0.061410|0.052287|0.500000| |3.464855|3.766205|4.825229|28.229718|3.075769|4.184103|3.497257|2.446588|0.072627|2.057088|1.958058|2.211814|3.823095|3.120400|1.861324|2.964032|1.916543|1.780665|1.763820|1.874602|2.029162|2.056038|4.071311|2.485348|2.670384|2.497224|2.255174|15.535060|7.324163|13.184872|16.579034|17.593153|8.898863|6.053470|0.083614|0.087504|0.109143|0.046563|0.045950|0.058231|0.059767|0.079620|0.069805|0.058146|0.302215|0.500000| |2.721527|3.150168|4.040970|29.514546|3.029080|3.812477|3.605471|2.688512|0.083509|2.241361|2.052261|2.239750|3.742895|3.239890|2.075970|3.261100|2.230818|2.076535|2.113726|2.326198|2.543935|2.480525|5.135873|2.742124|3.097939|2.814510|2.417441|16.323267|4.897176|7.449331|12.943250|8.697053|17.682775|9.155240|0.067939|0.070007|0.079430|0.053052|0.054634|0.075083|0.071516|0.098764|0.080407|0.061211|0.171995|0.203752|0.500000| |2.404034|2.620708|3.170264|21.507698|2.400660|3.146884|2.896794|2.089291|0.063778|1.828741|1.734962|1.893042|3.268138|2.810976|1.701424|2.734966|1.785278|1.655383|1.673138|1.831804|2.010471|1.978777|4.071572|2.035552|2.164374|1.982155|1.789285|12.553902|3.920000|6.683264|8.862113|6.939883|9.088386|17.691242|0.062487|0.060558|0.072027|0.042729|0.043519|0.059991|0.058179|0.066193|0.055438|0.046152|0.215808|0.154743|0.173454|0.500000| |2.168752|2.410221|2.905394|21.060880|2.332170|2.980051|2.874986|2.142792|0.066204|1.872288|1.739732|1.861628|3.156986|2.807648|1.771237|2.836281|1.903824|1.783710|1.838167|2.045711|2.232107|2.135393|4.631112|2.120907|2.316345|2.124916|1.879560|12.934918|3.401847|5.579200|7.819205|5.488617|9.107080|17.716476|0.056142|0.055697|0.063459|0.045635|0.047900|0.067580|0.061871|0.072402|0.060427|0.048352|0.142489|0.130259|0.218220|0.289143|0.500000|
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